A crucial enzyme in the mammalian brain seems to randomly switch on and off, according to new research reported in Nature. The V-ATPase enzyme normally generates energy to load neurotransmitters into ...

In a new breakthrough to understand more about the mammalian brain, University of Copenhagen researchers have made an incredible discovery. Namely, a vital enzyme that enables brain signals is ...

Vacuolar ATPases (V-ATPases) are rotary, multi-subunit proton pumps that harness the energy of ATP hydrolysis to acidify intracellular compartments and, in specialised cells, the extracellular milieu.

V-161, a novel compound targeting the Na+ -V-ATPase enzyme in vancomycin-resistant Enterococcus faecium (VRE), significantly reduces bacterial growth and colonization. A recent study has demonstrated ...

Alternating hemiplegia of childhood (AHC) is a rare, one-in-a-million genetic disease that affects kids. Most cases are caused by mutations in the ATP1A3 gene. That gene makes an ATPase enzyme that is ...

Molecular machines known as ATPases are one of the cell’s most important workhorses. Through stepwise contortions, each move fueled by the combustion of an ATP molecule, these enzymatic motors drive ...

The rap sheet for β-CTF is growing longer. The C-terminal fragment, produced when β-secretase cleaves APP, binds to—and blocks assembly of—vacuolar ATPase, a proton pump that fuels acidification of ...

F-Type ATP synthase, a catalytic complex of proteins, synthesizes adenosine triphosphate (ATP), the energy currency of living cells. A lot of ambiguity exists over the rotational mechanism of this ...

Enzymes are the molecular machines that power life; they build and break down molecules, copy DNA, digest food, and drive virtually every chemical reaction in our cells. For decades, scientists have ...

In a breakthrough to understand more about the mammalian brain, researchers have discovered that a vital enzyme that enables brain signals is switching on/off at random, even taking hours-long 'breaks ...