Inside every human cell, proteins are constantly being tagged with small chemical modifications after they're produced. Known as post-translational modifications, or PTMs, these can change how a ...

A new draft guidance from the US Food and Drug Administration (FDA) gives industry direction in how to assess drug-drug interactions for therapeutic proteins. The guidance, issued jointly by the ...

Researchers capture first-of-its-kind video of dynein–Lis1 protein interaction, supporting future drug development for neurological disorders. Our cells rely on microscopic highways and specialized ...

Many diseases are driven by proteins interacting with each other inside cells. But blocking these interactions with drugs is difficult because our typic “small-molecule” drugs often prove to be too ...

OverviewProteins are not static molecular objects but dynamic conformational ensembles whose structures, motions, disorder, ...