Targeting RBM5 may help disrupt 'undruggable' MYC in childhood leukemia

Scientists from St. Jude Children's Research Hospital and collaborators have identified the RNA-binding protein RBM5 as a ...
BioWorld

RNA-binding plus ribosomal proteins block c-Myc in lung cancer

Lung adenocarcinoma may be cornered by a recent finding coming from a study published on Nov. 30, 2023, in the Proceedings of the National Academy of Sciences. This investigation has unveiled that a ...
BioWorld

Suzhou Kintor Pharmaceuticals describes new PROTACS to induce degradation of c-Myc, GSPT1, IKZF2 and CK1α

Suzhou Kintor Pharmaceuticals Inc. has identified proteolysis targeting chimera (PROTAC) compounds comprising cereblon (CRBN) binding moiety covalently linked to Myc proto-oncogene protein (c-Myc), ...
Medical Xpress

Combining MYC inhibitors with metabolic drugs may boost cancer treatment efficacy

Northwestern Medicine investigators have discovered a new combination approach that may improve the efficacy of MYC inhibitor drugs for treating aggressive and treatment-resistant cancers, according ...
Healio

‘Amazing discovery’: Approach may curb Myc levels, stop fast-growing cancers

Please provide your email address to receive an email when new articles are posted on . Inhibiting RMB42 disrupted production of Myc proteins in pancreatic cancer cells. This approach could curtail ...
AlphaGalileo

AC004854.2: A novel prognostic biomarker and oncogenic driver in colorectal cancer

New study uncovers how SOX4-activated lncRNA disrupts the PUF60-FUBP1 complex to drive c-MYC transcription and tumor ...